Laboratoire d'algologie (nocions)

NOCIONS

Institute of Neuroscience - UCL

Laboratoire d'algologie

Pain is a major public healthcare issue. In addition to undermining the health and well being of millions of individuals, it imposes a severe financial burden upon our societies. Pain relief, particularly in the context of pathological chronic pain, constitutes a very problematic challenge to the physician. Therefore, progress in understanding the neural representation of pain in humans is not only important for basic neuroscience research. Indeed, it is also critical to develop effective strategies for the diagnosis and management of pathological pain conditions.

To progress in our understanding of the neural processes underlying the perception of pain, novel approaches are needed to identify and characterize activity specifically related to the processing of noxious input in humans. This constitutes the core objective of our research group, which combines novel methods to sample brain activity with novel methods to activate the nociceptive system in humans.

Specifically, the research activity of our lab is organized along two axes: (1) research on the physiology of the nociceptive system in humans (in particular, the cortical processes underlying the perception of pain) and (2) research on the pathophysiology of the nociceptive system in humans (in particular, the peripheral and central mechanisms leading to chronic pain). Both lines of research involve (3) the development of novel methods to activate the nociceptive system and (4) the development of novel methods to analyse neurophysiological data.

Research Papers Posters Talks Events Letswave Pictures Videos

Publications

Automated single-trial assessment of laser-evoked potentials as an objective functional diagnostic tool for the nociceptive system

Hatem SM, Hu L, Ragé M, Gierasimowicz-Fontana A, Plaghki L, Bouhassira D, Attal N, Iannetti GD, Mouraux A. Clin Neurophysiol (in press).

Thermal detection thresholds of A-delta and C-fibre afferents activated by brief CO2 laser pulses applied onto the human hairy skin.

Churyukanov M, Plaghki L, Legrain V, Mouraux A. PLoS ONE (2012) 7(4): e35817. [download PDF]

Gamma-band oscillations in the primary somatosensory cortex - a direct and obligatory correlate of subjective pain intensity.

Zhang ZG, Lu H, Hung YS, Mouraux A, Iannetti GD. J Neurosci (2012) (in press).

Efficient orienting of attention to the location of pain depends on the context in which it occurs.

Van Damme S, Legrain V. Pain (2012) (in press).

Assessment of chemosensory function using electroencephalographic techniques.

Rombaux P, Huart C, Mouraux A. Rhinology (2012) (in press). [download PDF]

Time-frequency analysis of chemosensory event-related potentials to characterize the cortical representation of odors in humans.

Huart C, Legrain V, Hummel T, Rombaux P, Mouraux A. PLoS ONE (2012) (in press). [download PDF]

Adaptation visuo-motrice et représentations corporelles: de la négligence au syndrome douloureux régional complexe.

Jacquin-Courtois S, Legrain V, Sumitani JP, Muyauchi S, Rossetti Y. La Lettre de Médecine Physique et de Réadaptation (2012) (in press). [download pdf]

Dishabituation of laser-evoked EEG responses: dissecting the effect of certain and uncertain changes in stimulus spatial location.

Torta DM, Liang M, Valentini E, Mouraux A, Iannetti GD. Exp Brain Res (2012) (in press). [download PDF]

Dyspnea-pain counter-irritation induced by inspiratory threshold loading: a laser evoked potentials study.

Bouvier G, La Violette L, Kindler F, Naccache L, Mouraux A, Similowski T, Morelot-Panzini C. J Appl Physiol (2012) (in press).

Pain, body, and space: what do patients with complex regional pain syndrome really neglect?

Legrain V, Bultitude JH, De Paepe A, Rossetti Y. Pain (2012) (in press) [download PDF].

Bypassing primary sensory cortices - a direct thalamocortical pathway for transmitting salient sensory information

Liang M, Mouraux A, Iannetti GD. Cereb Cortex (2012) (in press). [download PDF]

Steady-state evoked potentials to tag specific components of nociceptive cortical processing.

Colon E, Nozaradan S, Legrain V, Mouraux A. Neuroimage (2011); 60(1):571-581. [download PDF]

Steady-state evoked potentials as an index of multisensory temporal binding

Nozaradan S, Peretz I, Mouraux A. Neuroimage (2011); 60(1): 21-28. [download PDF]

Taking into account latency, amplitude and morphology: improved estimation of single-trial ERPs by wavelet filtering and multiple linear regression

Hu L, Liang M, Mouraux A, Wise RG, Hu Y, Iannetti GD. J Neurophysiol (2011); 106(6): 3216-29. [download PDF]

Tagging the neuronal entrainment to beat and meter

Nozaradan S, Peretz I, Missal M, Mouraux A. J Neurosci (2011) 31(28): 10234-40. [download PDF]

Parallel processing of nociceptive and non-nociceptive somatosensory information in the human primary and secondary somatosensory cortices: evidence from dynamic causal modelling of fMRI data

Liang M, Mouraux A, Iannetti GD. J Neurosci (2011) 31(24): 8976-85 [download PDF]

Nociceptive steady-state evoked potentials elicited by rapid periodic thermal stimulation of cutaneous nociceptors.

Mouraux A, Iannetti GD, Colon E, Legrain V, Nozaradan S, Plaghki L. J Neurosci (2011); 31(16): 6079-87. [download PDF]

Can the fMRI responses to physical pain really tell us why social rejection "hurts"?

Mouraux A, Iannetti GD. PNAS (2011) 108(30): E343 [letter] [download PDF]

Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis.

Huart C, Eloy P, Collet S, Rombaux P. Eur Arch Otorhinolaryngol (2011); 269(1):135-41. [download PDF]

Asymptomatic small fiber neuropathy in diabetes mellitus: investigations with intraepidermal nerve fiber density, quantitative sensory testing and laser-evoked potential.

Ragé M, Van Acker N, Knaapen MW, Timmers M, Streffer J, Hermans Mp, Sindic C, Meert T, Plaghki L. J Neurol (2011); 258(10):1852-64 [download PDF].

Multimodal therapeutic assessment of peripheral nerve stimulation in neuropathic pain: Five case reports with a 20-year follow-up.

Kupers R, Laere KV, Calenbergh FV, Gybels J, Dupont P, Baeck A, Plaghki L. Eur J Pain (2011); 15(2): 161.e1-9. [download PDF]

Born to dance but beat deaf: a new form of congenital amusia.

Phillips-Silver J, Toiviainen P, Gosselin N, Piché O, Nozaradan S, Palmer C, Peretz I. Neuropsychologia (2011); 49(5): 961-969

Chemosensory event-related potentials in early blind humans

Cuevas I, Plaza P, Rombaux P, Mouraux A, Delbeke J, Collignon O, De Volder AG, Renier L. B-ENT (2011); 7(1): 11-7.

Automated single-trial detection and quantification of evoked potentials, a potential tool for neuromonitoring?

Mouraux A, Guérit JM. Clin Neurophysiol (2011); 122(7): 1280-1. [download PDF]

The role of working memory in the attentional control of pain.

Legrain V, Crombez G, Verhoeven K, Mouraux A. Pain (2011); 152(2): 453-9. [download PDF]

Controlling attention to nociceptive stimuli with working memory

Legrain V, Crombez G, Mouraux A. PLoS ONE (2011) 6(6): e20926. [download PDF]

The Pain Matrix Reloaded. A Salience Detection System for the Body

Legrain V, Iannetti GD, Plaghki L, Mouraux A. Prog Neurobiol (2011) 93(1); 111-124. [download PDF]

Where is my pain?

Legrain V. Pain (2011); 152(3): 467-8. [download PDF]

Autonomic pain responses during sleep: a study of heart rate variability.

Chouchou F, Pichot V, Perchet C, Legrain V, Garcia-Larrea L, Barthélémy JC, Roche F, Bastuji H. Eur J Pain (2011) 15(6): 554-60.

Differential effects of painful and non-painful stimuli on tactile processing in fibromyalgia syndrome and subjects with masochistic behaviour.

Pollok B, Krause V, Legrain V, Ploner M, Freynhagen R, Melchior
I, Schnitzler A. PLoS ONE (2011); 5(12): e15804.

The role of spatial attention in attentional control over pain: an experimental investigation.

Van Ryckeghem D, Van Damme S, Crombez G, Eccleston C, Verhoeven K, Legrain V. Exp Brain Res (2011); 208(2): 269-275. [download PDF]

Is distraction from pain influenced by executive functioning abilities? An experimental investigation of task switching and inhibition

Verhoeven K, Van Damme S, Eccleston C, Van Ryckeghem D, Legrain V,
Crombez G. Eur J Pain (2011) 208(2): 269-75.

Dishabituation of laser-evoked EEG responses: dissecting the effect of certain and uncertain changes in stimulus modality

Valentini E, Torta D, Mouraux A, Iannetti GD. J Cog Neurosci (2011) (in press). [download PDF]

A multisensory investigation of the functional significance of the "pain matrix"

Mouraux A, Diukova A, Lee MC, Wise RG, Iannetti GD. Neuroimage (2011); 54(3):2237-49. [download PDF]

Keeping pain in mind: a motivational account of attention to pain.

Van Damme S, Legrain V, Vogt J, Crombez G. Neurosci Biobehav Rev (2010);34(2):204-213.

The time course of CO2 laser-evoked responses and of skin nerve fibre markers after topical capsaicin in human volunteers.

Ragé M, Van Acker N, Facer P, Shenoy R, Knaapen MW, Timmers M, Streffer J, Anand P, Meert T, Plaghki L. Clin Neurophysiol (2010) 121(8):1256-66. [download PDF]

The fine tuning of pain thresholds: a sophisticated double alarm system.

Plaghki L, Decruynaere C, Van Dooren P, Le Bars D. PLoS One (2010) 5(4):e10269. [download PDF]

Low intensity intra-epidermal electrical stimulation can activate Aδ-nociceptors selectively

Mouraux A, Iannetti GD, Plaghki L. Pain (2010) 150 (1):199-207. [download PDF]

From the Neuromatrix to the Pain Matrix (and back)

Iannetti GD, Mouraux A. Exp Brain Res (2010) 205(1):1-12. [download PDF]

$Stimulus novelty and not neural refractoriness explains the repetition suppression of laser-evoked potentials (LEPs)$

Stimulus novelty and not neural refractoriness explains the repetition suppression of laser-evoked potentials (LEPs)

Wang AL, Mouraux A, Liang M, Iannetti GD. J Neurophysiol (2010) 104(4):2116-24. [download PDF]

Tactile roughness discrimination threshold is unrelated to tactile spatial acuity.

Libouton X, Barbier O, Plaghki L, Thonnard JL. Behav Brain Res (2010); 208(2): 473-478.

Functional characterisation of sensory ERPs using probabilistic ICA: effect of stimulus modality and stimulus location.

Liang M, Mouraux A, Chan V, Blakemore C, Iannetti GD. Clin Neurophysiol (2010) 121(4):577-87. [download PDF]

Increased olfactory bulb volume and olfactory function in early blind subjects

Rombaux P, Huart C, De Volder AG, Cuevas I, Renier L, Duprez T, Grandin C. Neuroreport (2010); 21(17): 1067-1073. [download PDF]

Presence of olfactory event-related potentials predicts recovery in patients with olfactory loss following upper respiratory tract infection.

Rombaux P, Huart C, Collet S, Eloy P, Negoias S, Hummel T. Laryngoscope (2010); 120(10): 2115-2118. [download PDF]

A novel approach for enhancing the signal-to-noise ratio and detecting automatically event-related potentials (ERPs) in single trials.

Hu L, Mouraux A, Hu Y, Iannetti GD. Neuroimage (2010); 50(1):99-111. [download PDF]

Clinical, functional and structural determinants of central pain in syringomyelia

Hatem SM, Attal N, Ducreux D, Gautron M, Parker F, Plaghki L, Bouhassira D. Brain (2010); 133(11):3409-22. [download PDF]

An adaptive procedure for routine measurement of light-touch sensitivity threshold

Berquin AD, Lijesevic V, Blond S, Plaghki L. Muscle Nerve (2010); 42(3):328-38. [download PDF]

Why become more general when we can be more specific?

Van Damme S, Crombez G, Wiech K, Legrain V, Peters ML, Eccleston C. Pain 2009;144(3):342-343. Comment on Hollins et al. "Perceived intensity and unpleasantness of cutaneous and auditory stimuli: an evaluation of the generalized hypervigilance hypothesis" [Pain 2009;141:215-221], and on Rollman "Perspectives on hypervigilance" [Pain 2009;141:183-184]. author reply 343-344.

Long term clinical outcome of peripheral nerve stimulation in patients with chronic peripheral neuropathic pain.

Van Calenbergh F, Gybels J, Van Laere K, Dupont P, Plaghki L, Depreitere B, Kupers R. Surg Neurol 2009;72(4):330-335; discussion 335.

Usefulness and feasibility of psychophysical and electrophysiological olfactory testing in the rhinology clinic.

Rombaux P, Mouraux A, Collet S, Eloy P, Bertrand B. Rhinology 2009;47(1):28-35.

Are there nociceptive-specific brain potentials?

Mouraux A, Plaghki L, Iannetti GD. J Neurophysiol 2009;102(5):3075-3076

Nociceptive laser-evoked brain potentials do not reflect nociceptive-specific neural activity.

Mouraux A, Iannetti GD. J Neurophysiol 2009;101(6):3258-3269. [download PDF]

A neurocognitive model of attention to pain: behavioral and neuroimaging evidence.

Legrain V, Van Damme S, Eccleston C, Davis KD, Seminowicz DA, Crombez G. Pain 2009;144:230-232. [download PDF]

Involuntary orienting of attention to nociceptive events: neural and behavioral signatures.

Legrain V, Perchet C, Garcia-Larrea L. J Neurophysiol 2009;102(4):2423-2434. [download PDF]

Characterizing the cortical activity through which pain emerges from nociception.

Lee MC*, Mouraux A*, Iannetti GD. J Neurosci 2009;29(24):7909-7916. [download PDF]
*both authors contributed equally

Post-infectious olfactory loss: a cohort study and update.

Rombaux P, Martinage S, Huart C, Collet S. B-ENT (2009) 5 Suppl 13: 89-95.

Chemosensory pathways: from periphery to cortex.

Huart C, Collet S, Rombaux P. B-ENT (2009); 5 Suppl 13: 3-9 (Review).

Assessment of spinal somatosensory systems with diffusion tensor imaging in syringomyelia.

Hatem SM, Attal N, Ducreux D, Gautron M, Parker F, Plaghki L, Bouhassira D. J Neurol Neurosurg Psychiatry 2009;80(12):1350-1356. [download PDF]

How many response levels do children distinguish on faces scales for pain assessment?

Decruynaere C, Thonnard JL, Plaghki L. Eur J Pain 2009;13(6):641-648. [download PDF]

The enhancement of the N1 wave elicited by sensory stimuli presented at very short inter-stimulus intervals is a general feature across sensory systems.

Wang AL, Mouraux A, Liang M, Iannetti GD. PLoS ONE 2008;3(12):e3929. [download PDF]

Trigeminal event-related potentials in patients with olfactory dysfunction.

Rombaux P, Mouraux A, Keller T, Hummel T. Rhinology 2008;46(3):170-174.

Lateralisation of intranasal trigeminal chemosensory event-related potentials.

Rombaux P, Guerit JM, Mouraux A. Neurophysiol Clin 2008;38(1):23-30. [download PDF]

Evoked potentials to nociceptive stimuli delivered by CO(2) or Nd:YAP lasers.

Perchet C, Godinho F, Mazza S, Frot M, Legrain V, Magnin M, Garcia-Larrea L. Clin Neurophysiol 2008;119(11):2615-2622.

Across-trial averaging of event-related EEG responses and beyond.

Mouraux A, Iannetti GD. Magn Reson Imaging 2008;26(7):1041-1054. [download PDF]

A review of the evidence against the "first come first served" hypothesis.

Mouraux A, Iannetti GD. Comment on Truini et al. [Pain 2007;131:43-7]. Pain 2008;136(1-2):219-221; author reply 222-213. [download PDF]

Laser evoked responses to painful stimulation persist during sleep and predict subsequent arousals

Bastuji H, Perchet C, Legrain V, Montes C, Garcia-Larrea L. Pain (2008); 137(3):589-99.

La modulation de la douleur par l’attention. Les apports de la neurophysiologie. The modulation of pain by attention. Insights arising from neurophysiological studies.

Legrain V. Douleur & Analgésie (2008), 21:99-107

Les troubles de la somesthésie.

Laterre EC, Mouraux A. In: Sémiologie des maladies nerveuses (2008), Laterre EC (Ed.).

Intraoperative magnetic resonance imaging at 3-T using a dual independent operating room-magnetic resonance imaging suite: development, feasibility, safety, and preliminary experience

Jankovski A, Francotte F, Vaz G, Fomekong E, Duprez T, Van Boven M, Docquier MA, Hermoye L, Cosnard G, Raftopoulos C.
Neurosurgery. (2008) 63(3):412-24. [download PDF]

Intraoperative 3T MR imaging for spinal cord tumor resection: feasibility, timing, and image quality using a "twin" MR-operating room suite.

Duprez TP, Jankovski A, Grandin C, Hermoye L, Cosnard G, Raftopoulos C.
AJNR Am J Neuroradiol (2008) 29(10): 1991-4.

Combining EEG and fMRI in pain research.

Iannetti GD, Mouraux A. In: L Lemieux, C Mulert, editors. EEG-fMRI. New York: Springer-Verlag, 2008. p. (in press).

Determinants of laser-evoked EEG responses: pain perception or stimulus saliency?

Iannetti GD, Hughes NP, Lee MC, Mouraux A. J Neurophysiol 2008;100(2):815-828. [download PDF]

Peripheral and central determinants of a nociceptive reaction: an approach to psychophysics in the rat.

Benoist JM, Pincede I, Ballantyne K, Plaghki L, Le Bars D. PLoS ONE 2008;3(9):e3125.

Can we smell without an olfactory bulb?

Rombaux P, Mouraux A, Bertrand B, Duprez T, Hummel T. Am J Rhinol 2007;21(5):548-550.

Clinical significance of olfactory event-related potentials related to orthonasal and retronasal olfactory testing.

Rombaux P, Bertrand B, Keller T, Mouraux A. Laryngoscope 2007;117(6):1096-1101. [download PDF]

How do primates anticipate future events?

de Hemptinne C, Nozaradan S, Duvivier Q, Lefèvre P, Missal M. J Neurosci. (2007) 27:4334-41.

Are laser-evoked brain potentials modulated by attending to first or second pain?

Mouraux A, Plaghki L. Pain 2007;129(3):321-331. [download PDF]

Cortical interactions and integration of nociceptive and non-nociceptive somatosensory inputs in humans.

Mouraux A, Plaghki L. Neuroscience 2007;150(1):72-81. [download PDF]

Laser-evoked potentials correlate with clinical evolution in a case of spontaneous and recurrent complex regional pain syndrome type I.

Moreau V, Berquin AD, Plaghki L. Clin J Pain 2007;23(4):375-379. [download PDF]

Intra-operative MRI at 3T: short report.

Jankovski A, Raftopoulos C, Vaz G, Hermoye L, Cosnard G, Francotte F, Duprez T. JBR-BTR (2007) 90(4): 249-51.

How response inhibition modulates nociceptive and non-nociceptive somatosensory brain-evoked potentials

Hatem SM, Plaghki L, Mouraux A. Clin Neurophysiol 2007;118(7):1503-1516. [download PDF]

Measure of experimental pain using Rasch analysis.

Decruynaere C, Thonnard JL, Plaghki L. Eur J Pain 2007;11(4):469-474. [download PDF]

Olfactory function assessed with orthonasal and retronasal testing, olfactory bulb volume, and chemosensory event-related potentials.

Rombaux P, Weitz H, Mouraux A, Nicolas G, Bertrand B, Duprez T, Hummel T. Arch Otolaryngol Head Neck Surg 2006;132(12):1346-1351. [download PDF]

Retronasal and orthonasal olfactory function in relation to olfactory bulb volume in patients with posttraumatic loss of smell.

Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T. Laryngoscope 2006;116(6):901-905. [download PDF]

Olfactory function and olfactory bulb volume in patients with postinfectious olfactory loss.

Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T. Laryngoscope 2006;116(3):436-439. [download PDF]

Assessment of olfactory and trigeminal function using chemosensory event-related potentials.

Rombaux P, Mouraux A, Bertrand B, Guerit JM, Hummel T. Neurophysiol Clin 2006;36(2):53-62. [download PDF]

Valproate-induced hyperammonaemic encephalopathy revealing adult onset ornithine transcarbamylase deficiency: about an unusual case.

Ragé M, Nassogne M, Laloux P, Ossemann M. J Neurol. 2006 (253): 116.

Are the processes reflected by late and ultra-late laser evoked potentials specific of nociception?

Mouraux A, Plaghki L.Clin Neurophysiol 2006;59:197-204.

Psychophysical study of the effects of topical application of menthol in healthy volunteers.

Hatem S, Attal N, Willer JC, Bouhassira D. Pain 2006;122(1-2):190-196.

Somatotopic organization of the analgesic effects of motor cortex rTMS in neuropathic pain

Lefaucheur JP, Hatem S, Nineb A, Ménard-Lefaucheur I, Wendling S, Keravel Y, Nguyen JP. Neurology 2006;67:1998-2004.

Paucisymptomatic brainstem lesions revealing CNS schistosomiasis.

Rommel D, Rage M, Duprez T, Parent M, Sindic CJ. Acta Neurol Belg 2005;105(2):89-93.

Paucisymptomatic brainstem lesions revealing CNS schistosomiasis.

Rommel D, Ragé M, Duprez T, Parent M, Sindic CJ. Acta Neurol Belg. 2005 (105):89-93.

EEG and laser stimulation as tools for pain research.

Plaghki L, Mouraux A. Curr Opin Investig Drugs 2005;6(1):58-64. [download PDF]

Innocuous skin cooling modulates perception and neurophysiological correlates of brief CO2 laser stimuli in humans.

Nahra H, Plaghki L. Eur J Pain 2005;9(5):521-530. [download PDF]

Cognitive modulation of pain-related brain responses.

Legrain V, Plaghki L, Garcia-Larrea L. Comments on Seminowicz et al. (Pain 2004;112:48-58). Pain 2005;114(3):524-526; author reply 526-527. [download PDF]

Involuntary orientation of attention to unattended deviant nociceptive stimuli is modulated by concomitant visual task difficulty. Evidence from laser evoked potentials.

Legrain V, Bruyer R, Guerit JM, Plaghki L. Clin Neurophysiol 2005;116(9):2165-2174. [download PDF]

Critical review of oral drug treatments for diabetic neuropathic pain-clinical outcomes based on efficacy and safety data from placebo-controlled and direct comparative studies.

Adriaensen H, Plaghki L, Mathieu C, Joffroy A, Vissers K. Diabetes Metab Res Rev 2005;21(3):231-240.

Systematic overview of the pharmacological management of postherpetic neuralgia. An evaluation of the clinical value of critically selected drug treatments based on efficacy and safety outcomes from randomized controlled studies.

Plaghki L, Adriaensen H, Morlion B, Lossignol D, Devulder J. Dermatology 2004;208(3):206-216. [download PDF]

Single-trial detection of human brain responses evoked by laser activation of Adelta-nociceptors using the wavelet transform of EEG epochs.

Mouraux A, Plaghki L.Neurosci Lett 2004;361(1-3):241-244. [download PDF]

Refractoriness cannot explain why C-fiber laser-evoked brain potentials are recorded only if concomitant Adelta-fiber activation is avoided.

Mouraux A, Guerit JM, Plaghki L. Pain 2004;112(1-2):16-26. [download PDF]

Human non-phase-locked gamma oscillations in experience-based perception of visual scenes.

Goffaux V, Mouraux A, Desmet S, Rossion B. Neurosci Lett 2004;354(1):14-17.

Diagnostic colors contribute to the early stages of scenes categorization: behavioral and neurophysiological evidence.

Goffaux V, Jacques C, Mouraux A, Oliva S, Schyns PG, Rossion B. Visual Cognition (2004), 12, 878-892.

Affective associative learning modifies the sensory perception of nociceptive stimuli without participant's awareness.

Wunsch A, Philippot P, Plaghki L. Pain 2003;102(1-2):27-38. [download PDF]

How do we selectively activate skin nociceptors with a high power infrared laser? Physiology and biophysics of laser stimulation.

Plaghki L, Mouraux A. Neurophysiol Clin 2003;33(6):269-277. [download PDF]

Exogenous and endogenous components of ultralate (C-fibre) evoked potentials following CO2 laser stimuli to tiny skin surface areas in healthy subjects.

Opsommer E, Guerit JM, Plaghki L. Neurophysiol Clin 2003;33(2):78-85. [download PDF]

The effects of A-fiber pressure block on perception and neurophysiological correlates of brief non-painful and painful CO2 laser stimuli in humans.

Nahra H, Plaghki L. Eur J Pain 2003;7(2):189-199. [download PDF]

Modulation of perception and neurophysiological correlates of brief CO2 laser stimuli in humans using concurrent large fiber stimulation.

Nahra H, Plaghki L. Somatosens Mot Res 2003;20(2):139-147. [download PDF]

Non-phase locked electroencephalogram (EEG) responses to CO2 laser skin stimulations may reflect central interactions between A(delta)- and C-fibre afferent volleys.

Mouraux A, Guerit JM, Plaghki L. Clin Neurophysiol 2003;114(4):710-722. [download PDF]

Electrophysiological correlates of attentional orientation in humans to strong intensity deviant nociceptive stimuli, inside and outside the focus of spatial attention.

Legrain V, Guerit JM, Bruyer R, Plaghki L. Neurosci Lett 2003;339(2):107-110. [download PDF]

Nociceptive processing in the human brain of infrequent task-relevant and task-irrelevant noxious stimuli. A study with event-related potentials evoked by CO2 laser radiant heat stimuli.

Legrain V, Bruyer R, Guerit JM, Plaghki L. Pain 2003;103(3):237-248. [download PDF]

Recommendations for using opioids in chronic non-cancer pain.

Kalso E, Allan L, Dellemijn PL, Faura CC, Ilias WK, Jensen TS, Perrot S, Plaghki LH, Zenz M. Eur J Pain 2003;7(5):381-386.

Brain responses to signals ascending through C-fibers

Plaghki L, Mouraux A. In: K Hirata, editor. International Congress Series, Vol. 1232. Amsterdam: Elsevier, 2002. pp. 181-192. [download PDF]

Fulminant thrombotic thrombocytopenic purpura in the course of ciprofloxacin therapy.

Mouraux A, Gille M, Dorban S, Peeters A. Revue Neurologique (2002), 158, 1115-1117

Cortical venous thrombosis after lumbar puncture.

Mouraux A, Gille M, Dorban S, Peeters A. Journal of Neurology (2002), 249, 1313-1315

Attentional modulation of the nociceptive processing into the human brain: selective spatial attention, probability of stimulus occurrence, and target detection effects on laser evoked potentials.

Legrain V, Guerit JM, Bruyer R, Plaghki L. Pain 2002;99(1-2):21-39. [download PDF]

Complex regional pain syndrome: changing concepts and management strategies.

Plaghki L. JBR-BTR 2001;84(5):195-196.

Dipole analysis of ultralate (C-fibres) evoked potentials after laser stimulation of tiny cutaneous surface areas in humans.

Opsommer E, Weiss T, Plaghki L, Miltner WH. Neurosci Lett 2001;298(1):41-44. [download PDF]

Scalp topography of ultralate (C-fibres) evoked potentials following thulium YAG laser stimuli to tiny skin surface areas in humans.

Opsommer E, Weiss T, Miltner WH, Plaghki L. Clin Neurophysiol 2001;112(10):1868-1874. [download PDF]

Maturational changes in the thermoalgesic system in humans from childhood to adulthood revealed by CO(2) laser evoked brain potentials following cutaneous heat stimuli.

Opsommer E, Plaghki L. Neurosci Lett 2001;316(3):137-140. [download PDF]

Cardiorespiratory fitness, physical activity level, and chronic pain: are men more affected than women?

Nielens H, Plaghki L. Clin J Pain 2001;17(2):129-137. [download PDF]

Clinical and pathophysiological contribution of event-related potentials used to study migraine headache.

Legrain V, Janne P, Laloux P, Ossemann M, Dupuis M, Reynaert C.. Rev Neurol (Paris) 2001;157(4):365-375.

Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFRalpha signaling.

Spassky N, Heydon K, Mangatal A, Jankovski A, Olivier C, Queraud-Lesaux F, Goujet-Zalc C, Thomas JL, Zalc B. Development (2001) 128(24): 4993-5004.

Evaluation sensorielle quantitative : le thermotest et les poils de von Frey.

Plaghki L. L'observatoire de la douleur, 8, 2000, p. 50-54

Fonctions psychométriques et méthodes psychophysiques adaptatives pour l'étude de la douleur.

Mouraux A, Plaghki L. In: SFD-SOFRED, editor. Evaluation de la douleur expérimentale chez l'homme et l'animal. Paris, 2000.

L’apport des potentiels évoqués cognitifs à l’étude de la migraine: une approche psychophysiologique – Het belang van de cognitieve opgewekte potentialen bij de studie van migraine : een psychofysiologische benadering

Legrain V. Neurone/Neuron (2000), 5: 73-78

Consequences of neural cell adhesion molecule deficiency on cell migration in the rostral migratory stream of the mouse.

Chazal G, Durbec P, Jankovski A, Rougon G, Cremer H.
J Neurosci (2000) 15;20(4):1446-57.

Quantitative assessment of intrathecally administered baclofen in spasticity.

Detrembleur C, Plaghki L. Arch Phys Med Rehabil 2000;81(3):279-284.

Value of epidural steroid injections in low back pain and sciatica.

Van Zundert J, Plaghki L, Adriaensen H. Pain Digest, 9, 1999, p. 248-251.

Determination of nerve conduction velocity of C-fibres in humans from thermal thresholds to contact heat (thermode) and from evoked brain potentials to radiant heat (CO2 laser).

Opsommer E, Masquelier E, Plaghki L. Neurophysiol Clin 1999;29(5):411-422. [download PDF]

History taking - examination and management of ow back pain.

Masquelier E, Plaghki L. CME Tutorial 42 Pain digest, 9, 1999, p. 258-259. (Publié).

Evaluation des facteurs psychologiques liés aux céphalées de tension: revue des instruments psychométriques.

Legrain V, Ophoven E. Douleur & Analgésie (1999), 1: 101-110

Impaired selective attention in chronic pain patients.

Grisart JM, Plaghki LH. Eur J Pain 1999;3(4):325-333.

Facilitation of a nociceptive flexion reflex in man by nonnoxious radiant heat produced by a laser.

Plaghki L, Bragard D, Le Bars D, Willer JC, Godfraind JM. J Neurophysiol 1998;79(5):2557-2567. [download PDF]

Neuromodulation of pain. A consensus statement prepared in Brussels 16-18 January 1998 by the following task force of the European Federation of IASP Chapters (EFIC).

Gybels J, Erdine S, Maeyaert J, Meyerson B, Winkelmuller W, Augustinsson L, Bonezzi C, Brasseur L, DeJongste M, Kupers R, Marchettini P, Muller-Schwefe G, Nitescu P, Plaghki L, Reig E, Spincemaille G, Thomson S, Tronnier V, Van Buyten JP. Eur J Pain 1998;2(3):203-209.